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BioVaxys’ DPX outperforms traditional antigen delivery systems

Health Care, Market News
CSE:BIOV
31 October 2024 12:58 (EST)
Eyedropper and test tubes

(Source: Adobe Stock)

BioVaxys Technology (CSE: BIOV) has revealed significant findings from studies evaluating its innovative immune-educating delivery platform, DPX.

In a news release, the company stated that the research highlights that DPX effectively recruits and activates unique subsets of antigen-presenting cells (APCs), demonstrating superior immune activation compared with traditional aqueous and emulsion-based antigen delivery systems.

The success of cancer vaccines heavily depends on the effective delivery of antigenic APCs, which prime cytotoxic T cells to eradicate tumors.

Conventional peptide antigen delivery methods face limitations: water-based formulations provide only brief exposure to immune cells, while oil-in-water emulsions can lead to dysfunctional T-cell responses.

“These groundbreaking study results validate our strategic position in the multi-billion drug delivery market,” James Passin, CEO of BioVaxys, said in a statement. “DPX not only outperforms current solutions but also opens up significant revenue potential across various market segments.”

In contrast, BioVaxys’ DPX platform employs a non-aqueous, lipid-in-oil formulation that maintains the antigen at the injection site. This design ensures that the uptake of DPX-encapsulated antigens is actively driven by APCs over an extended period.

A collaborative study with Dalhousie University assessed the immune response dynamics of DPX compared with other formulations. Researchers utilized advanced techniques such as multi-parameter flow cytometry and confocal microscopy to analyze immune cell composition and antigen uptake in mice. The immune responses were evaluated through the interferon-gamma (IFN-γ) enzyme-linked immunospot (ELISpot) assay, a sensitive method for measuring immune cell activity.

Key findings from the study revealed:

“These findings underscore the quantitative and qualitative advantages of DPX in immune cell recruitment, showcasing its potential to enhance the efficacy of antigen delivery in immunotherapies,” Kenneth Kovan, COO of BioVaxys Technology, said.

As BioVaxys continues to advance its innovative technologies, these results position the company at the forefront of the evolving drug delivery landscape.

BioVaxys Technology is focused on improving patient lives with novel immunotherapies based on the DPX immune-educating technology platform and its HapTenix neoantigen tumor cell construct platform, for treating cancers, infectious disease, antigen desensitization and other immunological fields. 

Shares of BioVaxys Technology Corp. (CSE:BIOV) are down 6.67 per cent to C$0.07 as of 12:06 pm ET.

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(Top image: Adobe Stock)


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